Professor Simon Cool
Professor and Director of UQ Advanced Cell Therapy Manufacturing Initiative
School of Chemical Engineering
+61 7 336 54175
Researcher biography
Professor Simon Cool is Professor of Bioengineering and Director of the UQ Advanced Cell Therapy Manufacturing Initiative in the School of Chemical Engineering at the University of Queensland.
Professor Cool began his scientific career at the University of Queensland more than 20 years ago. He received his BSc (hons) and PhD degrees from the University of Queensland, where he subsequently held a faculty position in the School of Biomedical Sciences. His areas of studies have included age-related changes in the structure of bone and teeth and the extracellular matrix compartment of skeletal tissue that guide stem cell behaviour and wound repair. Professor Cool was invited to join the Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore in 2003 as a Principal Investigator. He then joined A*STAR's Institute of Medical Biology (IMB) in 2008, shortly after its inception, to further his research in regenerative medicine, serving as Senior Principal Investigator of the Glycotherapeutics Group. In October 2020, Professor Cool re-joined the Institute of Molecular and Cell Biology (IMCB) as a Research Director, Glycotherapeutics, where he focused on developing novel glycosaminoglycan biomolecules that enhance wound repair and control adult human mesenchymal stem cell activity.
Professor Cool has 117 patent applications across 26 families with 51 granted in the fields of glycosaminoglycan biochemistry, regenerative medicine and stem cell science. He has more than 150 publications and continues to foster strong strategic collaborations both nationally and internationally with academic and industry groups. He has a strong biomanufacturing and translational focus with experience in taking glycosaminoglycan-based devices through discovery RnD on to pre-clinical and clinical testing. Professor Cool also has an entrepreneurial and licensing background having successfully spun-off some of his technology to a US-based regenerative medicine start-up company, SMC Biotechnology Ltd. Professor Cool holds a Visiting Professor appointment at the Institute of Molecular and Cell Biology (IMCB), A*STAR, Singapore and an Adjunct Professor (Research) appointment in the Orthopaedic Department at the National University of Singapore (NUS). Prior to his move back to UQ, he previously held the position of Treasurer, Tissue Engineering and Regenerative Medicine International Society, Asia Pacific Chapter (TERMIS-AP) and Treasurer, Stem Cell Society Singapore (SCSS). He also held senior leadership positions in several Singapore-based R&D programmes, notably as Director, Allogeneic Stem Cell Manufacturing (ASTEM) and Theme Leader in Advanced Manufacturing for Biological Materials (AMBM). Prof Cool currently serves on the Editorial Board of the journals Biomaterials, Tissue Engineering and Regenerative Medicine, and is Asia-Pacific Regional Editor for Stem Cells and Development.
Journal Articles
Shaffer, Karl J., Smith, Raymond A. A., Daines, Alison M., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Schwörer, Ralf, Hinkley, Simon F. R., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2024). Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2. Carbohydrate Polymers, 333 121979, 121979. doi: 10.1016/j.carbpol.2024.121979
Daneshian, Yasaman, Lewallen, Eric A., Badreldin, Amr A., Dietz, Allan B., Stein, Gary S., Cool, Simon M., Ryoo, Hyun-Mo, Cho, Young Dan and van Wijnen, Andre J. (2024). Fundamentals and translational applications of stem cells and biomaterials in dental, oral and craniofacial regenerative medicine. Critical Reviews in Eukaryotic Gene Expression, 34 (6), 37-60. doi: 10.1615/CritRevEukaryotGeneExpr.2024053036
Smith, Raymond A. A., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Zubkova, Olga V., Tyler, Peter C., Nurcombe, Victor and Cool, Simon M. (2023). Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic. Biomaterials Advances, 155 213671, 1-17. doi: 10.1016/j.bioadv.2023.213671
Tan Kwan Zen, Nicholas, Zeming, Kerwin Kwek, Teo, Kim Leng, Loberas, Mavis, Lee, Jialing, Goh, Chin Ren, Yang, Da Hou, Oh, Steve, Hui Hoi Po, James, Cool, Simon M., Hou, Han Wei and Han, Jongyoon (2023). Scalable mesenchymal stem cell enrichment from bone marrow aspirate using deterministic lateral displacement (DLD) microfluidic sorting. Lab on a Chip, 23 (19), 4313-4323. doi: 10.1039/d3lc00379e
Luo, Xiaoman, Lau, Chau Sang, Le, Bach Quang, Tan, Tuan Chun, Too, Jian Hui, Smith, Raymond Alexander Alfred, Yu, Na and Cool, Simon M. (2023). Affinity-selected heparan sulfate collagen device promotes periodontal regeneration in an intrabony defect model in Macaca fascicularis. Scientific Reports, 13 (1) 11774, 1-15. doi: 10.1038/s41598-023-38818-y
Guo, Jiayi, Park, Eun Ju, Teo, Yew Chin, Abbas, Asyraf, Goh, Denise, Smith, Raymond Alexander Alfred, Nie, Yuntong, Nguyen, Hang T. L., Yeong, Joe Poh Sheng, Cool, Simon, Haruyuki, Makio and Teo, Peili (2023). Bioactive polyethylene by ring opening metathesis polymerization for potential orthopaedic applications. Polymer Chemistry, 14 (15), 1743-1751. doi: 10.1039/d2py01545e
Teo, Yew Chin, Park, Eun Ju, Guo, Jiayi, Abbas, Asyraf, Smith, Raymond Alexander Alfred, Goh, Denise, Yeong, Joe Poh Sheng, Cool, Simon and Teo, Peili (2022). Bioactive PCL-peptide and PLA-peptide brush copolymers for bone tissue engineering. ACS Applied Bio Materials, 5 (10), 4770-4778. doi: 10.1021/acsabm.2c00455
Srinivasan, Akshaya, Sathiyanathan, Padmapriya, Yin, Lu, Liu, Tong Ming, Lam, Alan, Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Loh, Han Ping, Zhang, Ying, Ling, Ling, Ng, Say Kong, Yang, Yuan Sheng, Lezhava, Alexander, Hui, James, Oh, Steve and Cool, Simon M. (2022). Strategies to enhance immunomodulatory properties and reduce heterogeneity in mesenchymal stromal cells during ex vivo expansion. Cytotherapy, 24 (5), 456-472. doi: 10.1016/j.jcyt.2021.11.009
Zhang, Ying, Ling, Ling, Ajayakumar, Arya Ajay D. O., Eio, Yating Michelle, van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2022). FGFR2 accommodates osteogenic cell fate determination in human mesenchymal stem cells. Gene, 818 146199, 146199. doi: 10.1016/j.gene.2022.146199
Sargison, Liam, Smith, Raymond A A, Carnachan, Susan M, Daines, Alison M, Brackovic, Amira, Kidgell, Joel T, Nurcombe, Victor, Cool, Simon M, Sims, Ian M and Hinkley, Simon F R (2022). Variability in the composition of porcine mucosal heparan sulfates. Carbohydrate Polymers, 282 119081. doi: 10.1016/j.carbpol.2021.119081
Cohen, Talia, Kossover, Olga, Peled, Eli, Bick, Tova, Hasanov, Lena, Chun, Tan Tuan, Cool, Simon, Lewinson, Dina and Seliktar, Dror (2022). A combined cell and growth factor delivery for the repair of a critical size tibia defect using biodegradable hydrogel implants. Journal of Tissue Engineering and Regenerative Medicine, 16 (4), 380-395. doi: 10.1002/term.3285
Hu, Tao, Liu, Ling, Lam, Raymond Wing Moon, Toh, Soo Yein, Abbah, Sunny Akogwu, Wang, Ming, Ramruttun, Amit Kumarsing, Bhakoo, Kishore, Cool, Simon, Li, Jun, Cho-Hong Goh, James and Wong, Hee-Kit (2021). Bone marrow mesenchymal stem cells with low dose bone morphogenetic protein 2 enhances scaffold-based spinal fusion in a porcine model. Journal of Tissue Engineering and Regenerative Medicine, 16 (1), 63-75. doi: 10.1002/term.3260
Hey, Hwee Weng Dennis, Lam, Wing Moon Raymond, Chan, Chloe Xiaoyun, Zhuo, Wen-Hai, Crombie, Elisa Marie, Tan, Tuan Chun, Chen, Way Cherng, Cool, Simon and Tsai, Shih Yin (2021). Paraspinal myopathy-induced intervertebral disc degeneration and thoracolumbar kyphosis in TSC1mKO mice model—a preliminary study. The Spine Journal, 22 (3), 483-494. doi: 10.1016/j.spinee.2021.09.003
Lui, Hayman, Samsonraj, Rebekah M., Vaquette, Cedryck, Denbeigh, Janet, Kakar, Sanjeev, Cool, Simon M., Dudakovic, Amel and Van Wijnen, Andre J. (2021). Combination of BMP2 and EZH2 inhibition to stimulate osteogenesis in a 3D bone reconstruction model. Tissue Engineering - Part A, 27 (15-16), 1084-1098. doi: 10.1089/ten.tea.2020.0218
Lui, Hayman, Denbeigh, Janet, Vaquette, Cedryck, Tran, Hoai My, Dietz, Allan B., Cool, Simon M., Dudakovic, Amel, Kakar, Sanjeev and van Wijnen, Andre J. (2021). Fibroblastic differentiation of mesenchymal stem/stromal cells (MSCs) is enhanced by hypoxia in 3D cultures treated with bone morphogenetic protein 6 (BMP6) and growth and differentiation factor 5 (GDF5). Gene, 788 145662, 1-11. doi: 10.1016/j.gene.2021.145662
Le, B. Q., Too, J. H., Tan, T. C., Smith, R. A. A., Nurcombe, , Cool, S. M. and Yu, N. (2021). Application of a BMP2-binding heparan sulphate to promote periodontal regeneration. European Cells and Materials, 42, 139-153. doi: 10.22203/eCM.v042a10
Zhang, Ying, Ravikumar, Maanasa, Ling, Ling, Nurcombe, Victor and Cool, Simon M. (2021). Age-related changes in the inflammatory status of human mesenchymal stem cells: Implications for cell therapy. Stem Cell Reports, 16 (4), 694-707. doi: 10.1016/j.stemcr.2021.01.021
Le, Bach Quang, Tan, Tuan Chun, Lee, Seong-Baek, Jang, Ju Woong, Kim, Young Sik, Lee, Jung Soo, Choi, Jae Won, Sathiyanathan, Padmapriya, Nurcombe, Victor and Cool, Simon M. (2021). A biomimetic collagen-bone granule-heparan sulfate combination scaffold for BMP2 delivery. Gene, 769 145217, 145217. doi: 10.1016/j.gene.2020.145217
Ravikumar, Maanasa, Smith, Raymond Alexander Alfred, Nurcombe, Victor and Cool, Simon M. (2020). Heparan sulfate proteoglycans: key mediators of stem cell function. Frontiers in Cell and Developmental Biology, 8 581213, 581213. doi: 10.3389/fcell.2020.581213
Chan, Su Jing, Esposito, Elga, Hayakawa, Kazuhide, Mandaville, Emiri, Smith, Raymond A. A., Guo, Shuzhen, Niu, Wanting, Wong, Peter Tsun-Hong, Cool, Simon M., Lo, Eng H. and Nurcombe, Victor (2020). Vascular endothelial growth factor 165-binding heparan sulfate promotes functional recovery from cerebral ischemia. Stroke, 51 (9), 2844-2853. doi: 10.1161/STROKEAHA.119.025304
Sathiyanathan, Padmapriya, Samsonraj, Rebekah M., Tan, Clarissa L. L., Ling, Ling, Lezhava, Alexander, Nurconnbe, Victor, Stanton, Lawrence W. and Cool, Simon M. (2020). A genomic biomarker that identifies human bone marrow-derived mesenchymal stem cells with high scalability. Stem Cells, 38 (9), 1124-1136. doi: 10.1002/stem.3203
Cool, Simon M., Sathiyanathan, Padmapriya, Samsonraj, Rebekah M., Tan, Clarissa L. L., Ling, Ling, Lezhava, Alexander, Nurcombe, Victor and Stanton, Lawrence W. (2020). In reply. Stem Cells, 38 (11), E7-E8. doi: 10.1002/stem.3264
Dudakovic, Amel, Samsonraj, Rebekah M., Paradise, Christopher R., Galeano-Garces, Catalina, Mol, Merel O., Galeano-Garces, Daniela, Zan, Pengfei, Galvan, M Lizeth, Hevesi, Mario, Pichurin, Oksana, Thaler, Roman, Begun, Dana L., Kloen, Peter, Karperien, Marcel, Larson, A. Noelle, Westendorf, Jennifer J., Cool, Simon M. and van Wijnen, Andre J. (2020). Inhibition of the epigenetic suppressor EZH2 primes osteogenic differentiation mediated by BMP2. The Journal of Biological Chemistry, 295 (23), 7877-7893. doi: 10.1074/jbc.RA119.011685
Liu, Tong Ming, Yildirim, Ege Deniz, Li, Pin, Fang, Hai Tong, Denslin, Vinitha, Kumar, Vibhor, Loh, Yuin Han, Lee, Eng Hin, Cool, Simon M., Teh, Bin Tean, Hui, James H., Lim, Bing and Shyh-Chang, Ng (2020). Ascorbate and iron are required for the specification and long-term self-renewal of human skeletal mesenchymal stromal cells. Stem Cell Reports, 14 (2), 210-225. doi: 10.1016/j.stemcr.2020.01.002
Ling, Ling, Ren, Xiafei, Cao, Xue, Hassan, Afizah Binte Mohd, Mah, Sophia, Sathiyanathan, Padmapriya, Smith, Raymond A. A., Tan, Clarissa L. L., Eio, Michelle, Samsonraj, Rebekah M., Van Wijnen, Andre J., Raghunath, Michael, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2020). Enhancing the efficacy of stem cell therapy with glycosaminoglycans. Stem Cell Reports, 14 (1), 105-121. doi: 10.1016/j.stemcr.2019.12.003
Nurcombe, Victor, Ling, Ling, Hondermarck, Hubert, Cool, Simon M. and Smith, Raymond A. A. (2019). Bringing heparan sulfate glycomics together with proteomics for the design of novel therapeutics: A historical perspective. Proteomics, 19 (21-22) 1800466, 1800466. doi: 10.1002/pmic.201800466
Titmarsh, Drew M., Nurcombe, Victor, Cheung, Christine and Cool, Simon M. (2019). Vascular cells and tissue constructs derived from human pluripotent stem cells for toxicological screening. Stem Cells and Development, 28 (20), 1347-1364. doi: 10.1089/scd.2018.0246
Lee, Jonathan H., Luo, Xiaoman, Ren, Xiafei, Tan, Tuan Chun, Smith, Raymond A.A., Swaminathan, Kunchithapadam, Sekar, Sakthivel, Bhakoo, Kishore, Nurcombe, Victor, Hui, James H. and Cool, Simon M. (2019). A heparan sulfate device for the regeneration of osteochondral defects. Tissue Engineering - Part A, 25 (5-6), 352-363. doi: 10.1089/ten.tea.2018.0171
Lim, Z. X.H., Rai, B., Tan, T. C., Ramruttun, A. K., Hui, J. H., Nurcombe, V., Teoh, S. H. and Cool, S. M. (2019). Autologous bone marrow clot as an alternative to autograft for bone defect healing. Bone and Joint Research, 8 (3), 107-117. doi: 10.1302/2046-3758.83.BJR-2018-0096.R1
Le, Bach Quang, Rai, Bina, Lim, Zophia Xue Hui, Tan, Tuan Chun, Lin, Tingxuan, Lee, Jaslyn Jie Lin, Murali, Sadasivam, Teoh, Swee Hin, Nurcombe, Victor and Cool, Simon McKenzie (2019). A polycaprolactone-beta-tricalcium phosphateeheparan sulphate device for cranioplasty. Journal of Cranio-Maxillofacial Surgery, 47 (2), 341-348. doi: 10.1016/j.jcms.2018.11.013
Smith, Raymond A.A., Murali, Sadasivam, Rai, Bina, Lu, Xiaohua, Lim, Zophia Xue Hui, Lee, Jaslyn J.L., Nurcombe, Victor and Cool, Simon M. (2018). Minimum structural requirements for BMP-2-binding of heparin oligosaccharides. Biomaterials, 184, 41-55. doi: 10.1016/j.biomaterials.2018.08.056
Poon, Selina, Lu, Xiaohua, Smith, Raymond A. A., Ho, Pei, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2018). Improved recovery from limb ischaemia by delivery of an affinity-isolated heparan sulphate. Angiogenesis, 21 (4), 777-791. doi: 10.1007/s10456-018-9622-9
Samsonraj, Rebekah M., Paradise, Christopher R., Dudakovic, Amel, Sen, Buer, Nair, Asha A., Dietz, Allan B., Deyle, David R., Cool, Simon M., Rubin, Janet and Van Wijnen, Andre J. (2018). Validation of osteogenic properties of cytochalasin D by high-resolution RNA-sequencing in mesenchymal stem cells derived from bone marrow and adipose tissues. Stem Cells and Development, 27 (16), 1136-1145. doi: 10.1089/scd.2018.0037
Yap, Lynn, Murali, Sadasivam, Bhakta, Gajadhar, Titmarsh, Drew M., Chen, Allen Kuan-Liang, Chiin Sim, Lyn, Bardor, Muriel, Lim, Yu Ming, Goh, James C.H., Oh, Steve K.W., Choo, Andre B.H., van Wijnen, Andre J., Robinson, David E., Whittle, Jason D., Birch, William R., Short, Robert D., Nurcombe, Victor and Cool, Simon M. (2018). Immobilization of vitronectin-binding heparan sulfates onto surfaces to support human pluripotent stem cells. Journal of Biomedical Materials Research - Part B Applied Biomaterials, 106 (5), 1887-1896. doi: 10.1002/jbm.b.33999
Soreide, Endre, Denbeigh, Janet M., Lewallen, Eric A., Samsonraj, Rebekah M., Berglund, Lawrence J., Dudakovic, Amel, Cool, Simon M., Nordsletten, Lars, Kakar, Sanjeev and van Wijnen, Andre J. (2018). Fibrin glue mediated delivery of bone anabolic reagents to enhance healing of tendon to bone. Journal of Cellular Biochemistry, 119 (7), 5715-5724. doi: 10.1002/jcb.26755
Smith, Raymond A. A., Chua, R. J. E., Carnachan, Susan M., Tan, Clarissa L. L., Sims, Ian M., Hinkley, Simon F. R., Nurcombe, Victor and Cool, Simon M. (2018). Retention of the structure and function of heparan sulfate biomaterials after gamma irradiation. Tissue Engineering - Part A, 24 (9-10), 729-739. doi: 10.1089/ten.tea.2017.0263
Su, Yan, Denbeigh, Janet M., Camilleri, Emily T., Riester, Scott M., Parry, Joshua A., Wagner, Eric R., Yaszemski, Michael J., Dietz, Allan B., Cool, Simon M., van Wijnen, Andre J. and Kakar, Sanjeev (2018). Extracellular matrix protein production in human adipose-derived mesenchymal stem cells on three-dimensional polycaprolactone (PCL) scaffolds responds to GDF5 or FGF2. Gene Reports, 10, 149-156. doi: 10.1016/j.genrep.2017.12.004
Samsonraj, Rebekah M., Dudakovic, Amel, Manzar, Bushra, Sen, Buer, Dietz, Allan B., Cool, Simon M., Rubin, Janet and van Wijnen, Andre J. (2018). Osteogenic stimulation of human adipose-derived mesenchymal stem cells using a fungal metabolite that suppresses the polycomb group protein EZH2. Stem Cells Translational Medicine, 7 (2), 197-209. doi: 10.1002/sctm.17-0086
Le, Bach Quang, Nurcombe, Victor, Cool, Simon McKenzie, van Blitterswijk, Clemens A., de Boer, Jan and LaPointe, Vanessa Lydia Simone (2017). The components of bone and what they can teach us about regeneration. Materials, 11 (1) 14, 14. doi: 10.3390/ma11010014
Bhakta, Gajadhar, Ekaputra, Andrew K., Rai, Bina, Abbah, Sunny A., Tan, Tuan Chun, Le, Bach Quang, Chatterjea, Anindita, Hu, Tao, Lin, Tingxuan, Arafat, M. Tarik, van Wijnen, Andre J., Goh, James, Nurcombe, Victor, Bhakoo, Kishore, Birch, William, Xu, Li, Gibson, Ian, Wong, Hee-Kit and Cool, Simon M. (2017). Fabrication of polycaprolactone-silanated β-tricalcium phosphate-heparan sulfate scaffolds for spinal fusion applications. Spine Journal, 18 (5), 818-830. doi: 10.1016/j.spinee.2017.12.002
Samsonraj, Rebekah M., Raghunath, Michael, Nurcombe, Victor, Hui, James H., van Wijnen, Andre J. and Cool, Simon M. (2017). Concise review: Multifaceted characterization of human mesenchymal stem cells for use in regenerative medicine. Stem Cells Translational Medicine, 6 (12), 2173-2185. doi: 10.1002/sctm.17-0129
Samsonraj, Rebekah M., Dudakovic, Amel, Zan, Pengfei, Pichurin, Oksana, Cool, Simon M. and Van Wijnen, Andre J. (2017). A versatile protocol for studying calvarial bone defect healing in a mouse model. Tissue Engineering - Part C: Methods, 23 (11), 686-693. doi: 10.1089/ten.tec.2017.0205
Chan, Su Jing, Love, Christopher, Spector, Myron, Cool, Simon M., Nurcombe, Victor and Lo, Eng H. (2017). Endogenous regeneration: Engineering growth factors for stroke. Neurochemistry International, 107, 57-65. doi: 10.1016/j.neuint.2017.03.024
Trott, Jamie, Tan, Ee Kim, Ong, Sheena, Titmarsh, Drew M., Denil, Simon L. I. J., Giam, Maybelline, Wong, Cheng Kit, Wang, Jiaxu, Shboul, Mohammad, Eio, Michelle, Cooper-White, Justin, Cool, Simon M., Rancati, Giulia, Stanton, Lawrence W., Reversade, Bruno and Dunn, N. Ray (2017). Long-term culture of self-renewing pancreatic progenitors derived from human pluripotent stem cells. Stem Cell Reports, 8 (6), 1675-1688. doi: 10.1016/j.stemcr.2017.05.019
Titmarsh, Drew M., Tan, Clarissa L. L., Glass, Nick R., Nurcombe, Victor, Cooper-White, Justin J. and Cool, Simon M. (2017). Microfluidic screening reveals heparan sulfate enhances human mesenchymal stem cell growth by modulating fibroblast growth factor-2 transport. Stem Cells Translational Medicine, 6 (4), 1178-1190. doi: 10.1002/sctm.16-0343
Ayerst, Bethanie I., Smith, Raymond A.A., Nurcombe, Victor, Day, Anthony J., Merry, Catherine L.R. and Cool, Simon M. (2017). Growth differentiation factor 5-mediated enhancement of chondrocyte phenotype is inhibited by heparin: implications for the use of heparin in the clinic and in tissue engineering applications. Tissue Engineering - Part A, 23 (7-8), 275-292. doi: 10.1089/ten.tea.2016.0364
Wijesinghe, Sampath Jeewantha, Ling, Ling, Murali, Sadasivam, Qing, Yeong Hui, Hinkley, Simon F.R., Carnachan, Susan M., Bell, Tracey J., Swaminathan, Kunchithapadam, Hui, James H., van Wijnen, Andre J., Nurcombe, Victor and Cool, Simon M. (2017). Affinity selection of FGF2-binding heparan sulfates for ex vivo expansion of human mesenchymal stem cells. Journal of Cellular Physiology, 232 (3), 566-575. doi: 10.1002/jcp.25454
Carnachan, Susan M., Bell, Tracey J., Sims, Ian M., Smith, Raymond A.A., Nurcombe, Victor, Cool, Simon M. and Hinkley, Simon F.R. (2016). Determining the extent of heparan sulfate depolymerisation following heparin lyase treatment. Carbohydrate Polymers, 152, 592-597. doi: 10.1016/j.carbpol.2016.07.024
Lewallen, Eric A., Bonin, Carolina A., Li, Xin, Smith, Jay, Karperien, Marcel, Larson, A. Noelle, Lewallen, David G., Cool, Simon M., Westendorf, Jennifer J., Krych, Aaron J., Leontovich, Alexey A., Im, Hee-Jeong and van Wijnen, Andre J. (2016). The synovial microenvironment of osteoarthritic joints alters RNA-seq expression profiles of human primary articular chondrocytes. Gene, 591 (2), 456-464. doi: 10.1016/j.gene.2016.06.063
Camilleri, Emily T., Gustafson, Michael P., Dudakovic, Amel, Riester, Scott M., Garces, Catalina Galeano, Paradise, Christopher R., Takai, Hideki, Karperien, Marcel, Cool, Simon, Sampen, Hee-Jeong Im, Larson, A. Noelle, Qu, Wenchun, Smith, Jay, Dietz, Allan B. and Van Wijnen, Andre J. (2016). Identification and validation of multiple cell surface markers of clinical-grade adipose-derived mesenchymal stromal cells as novel release criteria for good manufacturing practice-compliant production. Stem Cell Research and Therapy, 7 (1) 107, 1-16. doi: 10.1186/s13287-016-0370-8
Wang, Ming, Lam, Raymond W.M., Abbah, Sunny A., Hu, Tao, Toh, Soo Y., Cool, Simon, Bhakoo, Kishore, Li, Jun, Goh, James C.H. and Wong, Hee-Kit (2016). Heparin-based polyelectrolyte complex enhances the therapeutic efficacy of bone morphogenetic protein-2 for posterolateral fusion in a large animal model. Spine, 41 (15), 1199-1207. doi: 10.1097/BRS.0000000000001543
Ling, Ling, Camilleri, Emily T., Helledie, Torben, Samsonraj, Rebekah M., Titmarsh, Drew M., Chua, Ren Jie, Dreesen, Oliver, Dombrowski, Christian, Rider, David A., Galindo, Mario, Lee, Ian, Hong, Wanjin, Hui, James H., Nurcombe, Victor, van Wijnen, Andre J. and Cool, Simon M. (2016). Effect of heparin on the biological properties and molecular signature of human mesenchymal stem cells. Gene, 576 (1), 292-303. doi: 10.1016/j.gene.2015.10.039
Goonasekera, Chandhi S., Jack, Kevin S., Bhakta, Gajadhar, Rai, Bina, Luong-Van, Emma, Nurcombe, Victor, Cool, Simon M., Cooper-White, Justin J. and Grondahl, Lisbeth (2015). Mode of heparin attachment to nanocrystalline hydroxyapatite affects its interaction with bone morphogenetic protein-2. Biointerphases, 10 (4) 04A308, 1-12. doi: 10.1116/1.4933109
Lee, Jonathan, Wee, Sheena, Gunaratne, Jayantha, Chua, R. J. E., Smith, Raymond A. A., Ling, Ling, Fernig, David G., Swaminathan, Kunchithapadam, Nurcombe, Victor and Cool, Simon M. (2015). Structural determinants of heparin-transforming growth factor-β1 interactions and their effects on signaling. Glycobiology, 25 (12), 1491-1504. doi: 10.1093/glycob/cwv064
Rai, B., Chatterjea, A., Lim, Z. X.H., Tan, T. C., Sawyer, A. A., Hosaka, Y. Z., Murali, S., Lee, J. J.L., Fenwick, S. A., Hui, J. H., Nurcombe, V. and Cool, S. M. (2015). Repair of segmental ulna defects using a β-TCP implant in combination with a heparan sulfate glycosaminoglycan variant. Acta Biomaterialia, 28, 193-204. doi: 10.1016/j.actbio.2015.09.008
Okolicsanyi, Rachel K., Van Wijnen, Andre J., Cool, Simon M., Stein, Gary S., Griffiths, Lyn R. and Haupt, Larisa M. (2014). Heparan sulfate proteoglycans and human breast cancer epithelial cell tumorigenicity. Journal of Cellular Biochemistry, 115 (5), 967-976. doi: 10.1002/jcb.24746
Wang, Chunming, Poon, Selina, Murali, Sadasivam, Koo, Chuay-Yeng, Bell, Tracey J., Hinkley, Simon F., Yeong, Huiqing, Bhakoo, Kishore, Nurcombe, Victor and Cool, Simon M. (2014). Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy. Biomaterials, 35 (25), 6776-6786. doi: 10.1016/j.biomaterials.2014.04.084
Van Der Deen, Margaretha, Taipaleenmäki, Hanna, Zhang, Ying, Teplyuk, Nadiya M., Gupta, Anurag, Cinghu, Senthilkumar, Shogren, Kristen, Maran, Avudaiappan, Yaszemski, Michael J., Ling, Ling, Cool, Simon M., Leong, David T., Dierkes, Christian, Zustin, Jozef, Salto-Tellez, Manuel, Ito, Yoshiaki, Bae, Suk-Chul, Zielenska, Maria, Squire, Jeremy A., Lian, Jane B., Stein, Janet L., Zambetti, Gerard P., Jones, Stephen N., Galindo, Mario, Hesse, Eric, Stein, Gary S. and Van Wijnen, Andre J. (2013). MicroRNA-34c inversely couples the biological functions of the runt-related transcription factor RUNX2 and the tumor suppressor p53 in osteosarcoma. Journal of Biological Chemistry, 288 (29), 21307-21319. doi: 10.1074/jbc.M112.445890
Bhakta, Gajadhar, Sharma, Rakesh Kumar, Gupta, Nikesh, Cool, Simon, Nurcombe, Victor and Maitra, Amarnath (2011). Multifunctional silica nanoparticles with potentials of imaging and gene delivery. Nanomedicine: Nanotechnology, Biology, and Medicine, 7 (4), 472-479. doi: 10.1016/j.nano.2010.12.008
Tian, Jing, Ling, Ling, Shboul, Mohammad, Lee, Hane, O'Connor, Brian, Merriman, Barry, Nelson, Stanley F., Cool, Simon, Ababneh, Osama H., Al-Hadidy, Azmy, Masri, Amira, Hamamy, Hanan and Reversade, Bruno (2010). Loss of CHSY1, a secreted FRINGE enzyme, causes syndromic brachydactyly in humans via increased NOTCH signaling. American Journal of Human Genetics, 87 (6), 768-778. doi: 10.1016/j.ajhg.2010.11.005
Hernandez, Lidia, Roux, Kyle J., Wong, Esther Sook Miin, Mounkes, Leslie C., Mutalif, Rafidah, Navasankari, Raju, Rai, Bina, Cool, Simon, Jeong, Jae-Wook, Wang, Honghe, Lee, Hyun-Shik, Kozlov, Serguei, Grunert, Martin, Keeble, Thomas, Jones, C. Michael, Meta, Margarita D., Young, Stephen G., Daar, Ira O., Burke, Brian, Perantoni, Alan O. and Stewart, Colin L. (2010). Functional coupling between the extracellular matrix and nuclear lamina by wnt signaling in progeria. Developmental Cell, 19 (3), 413-425. doi: 10.1016/j.devcel.2010.08.013
Ekaputra, Andrew Krishna, Zhou, Yefang, Cool, Simon McKenzie and Hutmacher, Dietmar Werner (2009). Composite electrospun scaffolds for engineering tubular bone grafts. Tissue Engineering - Part A, 15 (12), 3779-3788. doi: 10.1089/ten.tea.2009.0186
Tonks, Ian D., Mould, Arne, Nurcombe, Victor, Cool, Simon M., Walker, Graeme J., Hacker, Elke, Keith, Patricia, Schroder, Wayne A., Cotterill, Andrew, Hayward, Nicholas K. and Kay, Graham F. (2009). Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo. Pigment Cell and Melanoma Research, 22 (3), 328-330. doi: 10.1111/j.1755-148X.2009.00560.x
Kumarasuriyar, A., Lee, I., Nurcombe, V. and Cool, S. M. (2009). De-sulfation of MG-63 cell glycosaminoglycans delays in vitro osteogenesis, up-regulates cholesterol synthesis and disrupts cell cycle and the actin cytoskeleton. Journal of Cellular Physiology, 219 (3), 572-583. doi: 10.1002/jcp.21700
Ling, Ling, Nurcombe, Victor and Cool, Simon M. (2009). Wnt signaling controls the fate of mesenchymal stem cells. Gene, 433 (1-2), 1-7. doi: 10.1016/j.gene.2008.12.008
Kumarasuriyar, A., Murali, S., Nurcombe, V. and Cool, S. M. (2009). Glycosaminoglycan composition changes with MG-63 osteosarcoma osteogenesis in vitro and induces human mesenchymal stem cell aggregation. Journal of Cellular Physiology, 218 (3), 501-511. doi: 10.1002/jcp.21620
Kumarasuriyar, Arjuna, Grondahl, Lisbeth, Nurcombe, Victor and Cool, Simon M. (2009). Osteoblasts up-regulate the expression of extracellular proteases following attachment to Poly(β-hydroxybutyrate-co-β-hydroxyvalerate). Gene, 428 (1-2), 53-58. doi: 10.1016/j.gene.2008.09.020
Dombrowski, Christian, Song, Shu Jun, Chuan, Peiying, Lim, Xinhong, Susanto, Evelyn, Sawyer, Amber A., Woodruff, Maria A., Hutmacher, Dietmar W., Nurcombe, Victor and Cool, Simon M. (2008). Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells. Stem Cells and Development, 18 (4), 661-670. doi: 10.1089/scd.2008.0157
Helledie, T., Nurcombe, V. and Cool, S. M. (2008). A simple and reliable electroporation method for human bone marrow mesenchymal stem cells. Stem Cells Dev, 17 (4), 837-848. doi: 10.1089/scd.2007.0209
Grunert, M., Nurcombe, V. and Cool, S. M. (2008). Stem Cell Fate Decisions: The Role of Heparan Sulfate in the Control of Autocrine and Paracrine Signals. Current Stem Cell Research and Therapy, 3 (1), 1-8. doi: 10.2174/157488808783489417
Nathan, S. S., Pereira, B. P., Zhou, Y. F., Gupta, A., Dombrowski, C., Soong, R., Pho, R. W., Stein, G. S., Salto-Tellez, M., Cool, S. M. and van Wijnen, A. J. (2008). Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma. Mol Biol Rep, 36 (1), 153-158. doi: 10.1007/s11033-008-9378-1
Ekaputra, A. K., Prestwich, G. D., Cool, S. M. and Hutmacher, D. W. (2008). Combining electrospun scaffolds with electrosprayed hydrogels leads to three-dimensional cellularization of hybrid constructs. Biomacromolecules, 9 (8), 2097-2103. doi: 10.1021/bm800565u
Rider, D. A., Dombrowski, C., Sawyer, A. A., Ng, G. H., Leong, D., Hutmacher, D. W., Nurcombe, V. and Cool, S. M. (2008). Autocrine fibroblast growth factor 2 increases the multipotentiality of human adipose-derived mesenchymal stem cells. Stem Cells, 26 (6), 1598-1608. doi: 10.1634/stemcells.2007-0480
Woodruff, Maria Ann, Rath, Subha Narayan, Susanto, Evelyn, Haupt, Larisa M., Hutmacher, Dietmar W., Nurcombe, Victor and Cool, Simon M. (2007). Sustained release and osteogenic potential of heparan sulfate-doped fibrin glue scaffolds within a rat cranial model. Journal of Molecular Histology, 38 (5), 425-433. doi: 10.1007/s10735-007-9137-y
Luong-Van, E, Grondahl, L, Song, SJ, Nurcombe, V and Cool, S (2007). The in vivo assessment of a novel scaffold containing heparan sulfate for tissue engineering with human mesenchymal stem cells. Journal of Molecular Histology, 38 (5), 459-468. doi: 10.1007/s10735-007-9129-y
Hutmacher, D. W. and Cool, S. (2007). Concepts of scaffold-based tissue engineering - The rationale to use solid free-form fabrication techniques. Journal of Cellular and Molecular Medicine, 11 (4), 654-669. doi: 10.1111/j.1582-4934.2007.00078.x
Keen, I., Raggatt, L.J., Cool, S.M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2007). Investigations into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) surface properties causing delayed osteoblast growth. Journal of Biomaterials Science-polymer Edition, 18 (9), 1101-1123. doi: 10.1163/156856207781554046
Cool, SM, Kenny, B, Wu, A, Nurcombe, V, Trau, M, Cassady, AI and Grondahl, L (2007). Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) composite biomaterials for bone tissue regeneration: In vitro performance assessed by osteoblast proliferation, osteoclast adhesion and resorption, and macrophage proinflammatory response. Journal of Biomedical Materials Research Part A, 82A (3), 599-610. doi: 10.1002/jbm.a.31174
Luong-Van, E, Grondahl, L, Nurcombe, V and Cool, S (2007). In vitro biocompatibility and bioactivity of microencapsulated heparan sulfate. Biomaterials, 28 (12), 2127-2136. doi: 10.1016/j.biomaterials.2007.01.002
Song, SJ, Cool, SM and Nurcombe, V (2007). Regulated expression of syndecan-4 in rat calvaria osteoblasts induced by fibroblast growth factor-2. Journal of Cellular Biochemistry, 100 (2), 402-411. doi: 10.1002/jcb.21068
Woei Ng, K, Speicher, T, Dombrowski, C, Helledie, T, Haupt, LM, Nurcombe, V and Cool, SM (2007). Osteogenic differentiation of murine embryonic stem cells is mediated by fibroblast growth factor receptors.. Stem Cells and Development, 16 (2), 305-318. doi: 10.1089/scd.2006.0044
Manton, KJ, Haupt, LM, Vengadasalam K, Nurcombe V and Cool SM (2007). Glycosaminoglycan and growth factor mediated murine calvarial cell proliferation. Journal of Molecular Histology, 38 (5), 415-424. doi: 10.1007/s10735-007-9121-6
Nurcombe, V, Goh, FJ, Haupt, LM, Murali, S and Cool, SM (2007). Temporal and functional changes in glycosaminoglycan expression during osteogenesis.. Journal of Molecular Histology, 38 (5), 469-481. doi: 10.1007/s10735-007-9123-4
Rider, DA, Nalathamby, T, Nurcombe, V and Cool, SM (2007). Selection using the alpha-1 integrin (CD49a) enhances the multipotentiality of the mesenchymal stem cell population from heterogeneous bone marrow stromal cells. Journal of Molecular Histology, 38 (5), 449-458. doi: 10.1007/s10735-007-9128-z
Manton, KJ, Leong, DF, Cool, SM and Nurcombe, V (2007). Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways.. Stem Cells: the international journal of cell differentiation and proliferation, 25 (11), 2845-2854. doi: 10.1634/stemcells.2007-0065
Nurcombe, V and Cool, SM (2007). Heparan sulfate control of proliferation and differentiation in the stem cell niche.. Critical Reviews in Eukaryotic Gene Expression, 17 (2), 159-171.
Cool SM (2007). Control of cell fate decisions.. Journal of Molecular Histology, 38 (5), 377-379. doi: 10.1007/s10735-007-9146-x
Kumarasuriyar, A, Dombrowski, C, Rider, DA, Nurcombe, V and Cool, SM (2007). A novel use of TAT-EGFP to validate techniques to alter osteosarcoma cell surface glycosaminoglycan expression. Journal of Molecular Histology, 38 (5), 435-447. doi: 10.1007/s10735-007-9136-z
Grunert, M, Dombrowski, C, Sadasivam, M, Manton, K, Cool, SM and Nurcombe, V (2007). Isolation of a native osteoblast matrix with a specific affinity for BMP2. Journal of Molecular Histology, 38 (5), 393-404. doi: 10.1007/s10735-007-9119-0
Jackson, RA, Murali, S, Van Wijnen, AJ, Stein, GS, Nurcombe, V and Cool, SM (2007). Heparan sulfate regulates the anabolic activity of MC3T3-E1 preosteoblast cells by induction of Runx2. Journal of Cellular Physiology, 210 (1), 38-50. doi: 10.1002/jcp.20813
Zhen, Chum Zhi, Woodruff, M. A., Sugunan, Suman Lal Chirammal, Cool, S. M., Nurcombe, V. and Hutmacher, D. W. (2006). Characterisation and differentiation of porcine bone marrow mesenchymal stem cells in 2D and 3D mPCL-TCP-collagen scaffolds. European Cells and Materials, 11 (S2), 82-82.
Luong-Van, Emma, Grondahl, Lisbeth, Chua, Kian Ngiap, Leong, Kam W., Nurcombe, Victor and Cool, Simon M. (2006). Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. Biomaterials, 27 (9), 2042-2050. doi: 10.1016/j.biomaterials.2005.10.028
Ling,, Sadasivam,, Dombrowski,, Haupt, L. M., Stein,, Van Wijnen,, Nurcombe, V and Cool, S M (2006). Sulfated Glycosaminoglycans Mediate the Effects of FGF2 on the Osteogenic Potential of Rat Calvarial Osteoprogenitor Cells. Journal Of Cellular Physiology, 209 (3), 811-825. doi: 10.1002/jcp.20760
Jackson, A, Nurcombe, V and Cool, S M (2006). Coordinated fibroblast growth factor and heparan sulfate regulation of osteogenesis. Gene, 379, 79-91. doi: 10.1016/j.gene.2006.04.028
Cool, S M and Nurcombe, V (2006). Heparan Sulfate Regulation of Progenitor Cell Fate. Journal of Cellular Biochemistry, 99 (4), 1040-1051. doi: 10.1002/jcb.20936
Manton, J., Sadasivam,, Cool, S M and Nurcombe, V (2006). Bone-Specific Heparan Sulfates Induce Osteoblast Growth Arrest and Downregulation of Retinoblastoma Protein. Journal Of Cellular Physiology, 209 (1), 219-229. doi: 10.1002/jcp.20727
Jackson, RA, Kumarasuriyar, A, Nurcombe, V and Cool, SM (2006). Long-term loading inhibits ERK1/2 phosphorylation and increases FGFR3 expression in MC3T3-E1 osteoblast cells. Journal of Cellular Physiology, 209 (3), 894-904. doi: 10.1002/jcp.20779
Song, J., Hutmacher, D., Nurcombe, V. and Cool, S. M. (2006). Temporal expression of proteoglycans in the rat limb during bone healing. Gene, 379, 92-100. doi: 10.1016/j.gene.2006.04.029
Cool, S. M., Grunert, M., Jackson, R., Li, H., Nurcombe, V. and Waters, M. J. (2005). Role of growth hormone receptor signaling in osteogenesis from murine bone marrow progenitor cells. Biochemical And Biophysical Research Communications, 338 (2), 1048-1058. doi: 10.1016/j.bbrc.2005.10.035
Chipperfield, H, Cool, SM, Bedi, K and Nurcombe, V (2005). Adult CNS explants as a source of neural progenitors. Brain Research Protocols, 14 (3), 146-153. doi: 10.1016/j.brainresport.2004.12.003
Cool, Simon M., Synman, Charles P., Nurcombe, Victor and Forwood, Mark (2004). Temporal expression of fibroblast growth factor receptors during primary ligament repair. Knee Surgery Sports Traumatology Arthroscopy, 12 (5), 490-496. doi: 10.1007/s00167-003-0444-x
Hogg, R. C., Chipperfield, H., Whyte, K. A., Stafford, M. R., Hansen, M. A., Cool, S. M., Nurcombe, V. and Adams, D. J. (2004). Functional maturation of isolated neural progenitor cells from the adult rat hippocampus. European Journal of Neuroscience, 19 (9), 2410-2420. doi: 10.1111/j.0953-816X.2004.03346.x
Cool, S. M., Forwood, M. R., Campbell, P. and Bennett, M. B. (2002). Comparisons between bone and cementum compositions and the possible basis for their layered appearances. Bone, 30 (2), 386-392. doi: 10.1016/S8756-3282(01)00686-X
Cool, S. M., Sayer, R. E., van Heumen, W. R., Pickles, J. O. and Nurcombe, V. (2002). Temporal and spatial expression of fibroblast growth factor receptor 4 isoforms in murine tissues. Histochemical Journal, 34 (6-7), 291-297. doi: 10.1023/A:1023326524562
Chipperfield, H., Bedi, K. S., Cool, S. M. and Nurcombe, V. (2002). Heparan sulfates isolated from adult neural progenitor cells can direct phenotypic maturation. International Journal of Developmental Biology, 46 (4), 1-6.
Cool, S, Jackson, R, Pincus, P, Dickinson, I and Nurcombe, V (2002). Fibroblast growth factor receptor 4 (FGFR4) expression in newborn murine calvaria and primary osteoblast cultures. International Journal of Developmental Biology, 46 (4), 519-523.
Descamps, S, Toillon, RA, Adriaenssens, E, Pawlowski, V, Cool, SM, Nurcombe, V, Le Bourhis, XF, Boilly, B, Peyrat, JP and Hondermarck, H (2001). Nerve growth factor stimulates proliferation and survival of human breast cancer cells through two distinct signaling pathways. Journal of Biological Chemistry, 276 (21), 17864-17870. doi: 10.1074/jbc.M010499200
Nurcombe, Victor, Smart, Chanel E., Chipperfield, Hiram, Cool, Simon M., Boilly, Benoni and Hondermarck, Hubert (2000). The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. Journal of Biological Chemistry, 275 (39), 30009-30018. doi: 10.1074/jbc.M003038200
Conference Papers
Shokoohmand, A., Srinivasan, A., Ling, L., Silva, F. Rodrigues de Oliveira, Eio, M.Y., Lu, X., Loberas, M., Tao, K., Tan, C., Nurcombe, V., Hui, J., Smith, R. and Cool, S. (2024). Preserving clinical efficacy of mesenchymal stem cells with glycosaminoglycan additives. 30th Annual ISCT Meeting, Vancouver, BC, Canada, 29 May - 1 June 2024. Oxford, United Kingdom: Elsevier. doi: 10.1016/j.jcyt.2024.03.116
Titmarsh, D., Glass, N., Nurcombe, V., Cooper-White, J. and Cool, S. (2015). High-throughput microfluidic screening of human mesenchymal Stem Cell proliferative responses to FGF-2 and heparan sulfates. 4th TERMIS World Congress, Boston, MA USA, 8-11 September 2015. New Rochelle, NY USA: Mary Ann Liebert.
Gomathy, S. S., Stylianou, C., Phang, I. Y., Cool, S., Nurcombe, V., Ample, F., Lear, M. J., Gorelik, S. and Hobley, J. (2010). Raman mapping glucose metabolism during adipogenesis from human mesenchymal stem cells. Photonics Global Conference, Orchard, Singapore, 14-16 December 2010. Piscataway, NJ, United States: Institute of Electrical and Electronics Engineers. doi: 10.1109/PGC.2010.5705978
Sawyer, Amber A., Lim, Xinhong, Hosaka, Yoshi, Rider, David A., Poh, Wei Theng, Hui, James, Doshi, Hitendra, Nurcombe, Vic and Cool, Simon (2008). Heparan sulfate promotes human mesenchymal stem cell growth and viability in vitro and stimulates bone repair in vivo. World Biomaterials Congress, _, _.
Grondahl, L, Keen, I, Raggatt, L, Chandler-Temple, A. F., Cool, S M and Trau, M (2006). Tailoring poly(3-hydroxybutyrate-co-3-hydroxyvalerate) for bone tissue engineering. 28th Australasian Polymer Symposium & Aust Society for Biomat, Rotorua, 5-9 Feb, 2006.
Raggatt, L. J., Qin, L., Cool, S., Nurcombe, V. and Partridge, N. (2005). Parathyroid hormone stimulation of syndecan-4 in osteoblastic cells.. 27th Annual Meeting of the American-Society-for-Bone-and-Mineral-Research, Nashville, TN USA, 23-27 September 2005. Hoboken, NJ USA: Wiley-Blackwell Publishing.
Luong-Van, E. K., Grondahl, L., Chua, K.B., Leong, K.C., Nurcombe, V. and Cool, S. M. (2005). Electrospun polycaprolactone fiber membranes for the sustained delivery of heparin. Indo-Australian Conference on Biomaterials, Implantable Devicg, India, Jan, 2005.
Grondahl, L., Lawrie, G. A. and Cool, S. M. (2005). Characterisation of alginate and hydroxyapatite/alginate drug delivery systems. Aust Society for Biomaterials 14th Annual Conference, Victor Harbor, Mar, 2005.
Keen, I., Raggatt, L., Cool, S. M., Nurcombe, V., Fredericks, P., Trau, M. and Grondahl, L. (2005). Response of osteoblast cells to the surface properties of Poly(3-hydroxybutyrate-co-hydroxyvalerate) PHBV. 2nd ARC Centre For Functional Nanomaterials Annual Conference, Maroochydore, Nov, 2005.
Kumarasuriyar, A., Jackson, R. A., Grondahl, L., Trau, M., Nurcombe, V. and Cool, S. M. (2005). Poly(beta-hydroxybutyrate-co-beta-hydroxyvalerate) supports in vitro osteogenesis. New Rochelle: Mary Ann Liebert Inc. doi: 10.1089/ten.2005.11.1281
Raggatt, J. L., Qin, L., Cool, S. M., Nurcombe, V. and Partridge N. C. (2005). Parathyroid hormone stimulation of Syndecan-4 in osteoblastic cells. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN USA, 24-26 September, 2005. Malden, MA USA: American Society for Bone and Mineral Research.
Raggatt, J. L., Qin, L., Cool, S. M., Nurcombe, V. and Partridge, N. C. (2005). Parathyroid hormone regulation of syndecan-4 in osteoblast cells. 27th Annual Meeting of the American Society for Bone and Mineral Research, Nashville, TN USA, 23-27 September 2005. Washington, DC USA: Wiley-Blackwell.
Keen, I., Grondahl, L., Cool, S. M., Nurcombe, V. and Trau, M. (2004). Surface modification of PHBV for bone tissue engineering. 7th World Biomaterials Congress, Sydney, May, 2004.
Grondahl, L., Lutton, C. J., Kenny, B., Cool, S. M., Cassady, A.I. and Trau, M. (2004). Development and in vitro testing of a biodegradable bone scaffold. 7th World Biomaterials Congress, Sydney, May, 2004.
Keen, I., Grondahl, L., Raggatt, L., Fredericks, P.M., Nurcombe, V., Trau, M. and Cool, S. M. (2004). Influence of solvent on the surface properties of PHBV solvent cast films. 27th Australasian Polymer Symposium, Adelaide, Nov, 2004.
Luong-Van, E. K., Grondahl, L., Nurcombe, V. and Cool, S. M. (2004). Heparan sulfate loaded Poly( -caprolactone) microparticles for bone repair. 7th World Biomaterials Congress, Sydney, May, 2004.
Kumarasuriyar, A., Jackson, R., Grondahl, L., Trau, M., Nurcombe, V. and Cool, S. M. (2004). In vitro analysis of a bioactive, biodegradable material for bone repair. 7th World Biomaterials Congress, Sydney, May, 2004.
Kippers, V., Cool, S. and Aland, R. C. (2004). Teaching gross anatomy in a PBL-based medical curriculum. 16th International Congress of the International Federation of Associations of Anatomists (IFAA 2004): Morphological Sciences as the Basis of New Life Science in the 21st Century, Kyoto International Conference Hall, Kyoto, Japan, 22-27 August 2004. Victoria: Blackwell Publishing Asia.
Grondahl, L., Chandler-Temple, A. F., Luong-Van, E. K., Riding, A. S., Kumarasuriyar, A., Kenny, B., Cool, S. M., Nurcombe, V., Whittaker, A. K., Cassady, I.A. and Trau, M. (2003). Biodegradable polyester materials: Uses in bone regeneration. 26th Australian Polymer Conference, Noosa, July, 2003.
Chandler-Temple, A. F., Grondahl, L., Trau, M., Cool, S. M. and Nurcombe, V. (2003). Surface modification for PHBV for enhanced biocompatibility. 13th Annual Conference of Australian Society for Biomaterials, Brisbane, March, 2003.
Jackson, R., Nurcombe, V. and Cool, S. M. (2001). Fluid shear stress as a mediator of fibroblast growth factor receptor (FGFR) expression and osteoblast phenotype. Australia and New Zealand Bone and Mineral Society 11th Annual Scientific Meeting, Auckland, NZ, October 2001.
Cool, S. M., Jackson, R., Campbell, J. H. and Nurcombe, V. (2001). Peritoneal fluid: a potential source of stem cells with osteogenic potential?. Australia and New Zealand Bone and Mineral Society 11th Annual Scientific Meeting, Auckland, NZ, October 2001.