Dr Dalila Iannotta

Postdoctoral Research Fellow

School of Chemical Engineering

d.iannotta@uq.edu.au

Researcher biography

Dr. Dalila Iannotta obtained her PhD in Cellular and Molecular Biotechnology in 2022. Her goal is to contribute to nanomedicine by developing new delivery systems that decrease side effects and increase the therapeutic activity of medicines.

She has over eight years of research experience in various areas, such as extracellular vesicles, synthetic nanoparticles, and disease models (wounds and neurological conditions). Her research has resulted in nine publications, including in journals such as the Nature Nanotechnology (IF: 38.1), Journal of Extracellular Vesicles (IF: 21.22) and Nano Today (IF: 18.96).

She has mentored 16 Master's degree students and five undergraduate students at various institutions, including at The University of Queensland (Australia), Mayo Clinic (USA) (ranked best hospital in the world, Newsweek), D'Annunzio University of Chieti–Pescara (Italy), and University of L'Aquila (Italy). She has also taken an active role in the "Young Scientists" program for high school students.

Main research fields:

Hybrid delivery systems: design new hybrid nanosystems consisting of synthetic nanoparticles and extracellular vesicles for a best-of-both worlds approach that enables delivery of therapeutic peptides.
Advanced purification methods for extracellular vesicles: develop improved purification methods for extracellular vesicles derived from biofluids, such as plasma.

Publications

Journal Articles (16)

Conference Papers (3)

Journal Articles

Iannotta, Dalila, A, Amruta, Kijas, Amanda W., Rowan, Alan E. and Wolfram, Joy (2023). Entry and exit of extracellular vesicles to and from the blood circulation. Nature Nanotechnology, 19 (1), 137-20. doi: 10.1038/s41565-023-01522-z

Iannotta, Dalila, Amruta A., Lai, Andrew, Nair, Soumyalekshmi, Koifman, Na'ama, Lappas, Martha, Salomon, Carlos and Wolfram, Joy (2023). Chemically‐Induced Lipoprotein Breakdown for Improved Extracellular Vesicle Purification. Small, 20 (18) 2307240, 1-14. doi: 10.1002/smll.202307240

Iannotta, Dalila, Goncalves, Jenifer P., Ghebosu, Raluca E., Gopalakrishnan, Aswathi, Cooper-White, Justin and Wolfram, Joy (2023). Transforming undergraduate laboratory courses with interlinked real-world challenges. Trends in Biotechnology, 42 (1), 1-4. doi: 10.1016/j.tibtech.2023.10.006

Amruta, A., Iannotta, Dalila, Cheetham, Seth W., Lammers, Twan and Wolfram, Joy (2023). Vasculature organotropism in drug delivery. Advanced Drug Delivery Reviews, 201 115054, 1-13. doi: 10.1016/j.addr.2023.115054

Chen, Siyu, Iannotta, Dalila, O'Mara, Megan L., Goncalves, Jenifer Pendiuk and Wolfram, Joy (2023). Extracellular vesicle lipids in cancer immunoevasion. Trends in Cancer, 9 (11), 883-886. doi: 10.1016/j.trecan.2023.08.006

Goncalves, Jenifer P., Ghebosu, Raluca E., Tan, Xuan Ning Sharon, Iannotta, Dalila, Koifman, Na'ama and Wolfram, Joy (2023). Hyaluronic acid: An overlooked extracellular vesicle contaminant. Journal of Extracellular Vesicles, 12 (9) 12362, e12362. doi: 10.1002/jev2.12362

Scurti, Elena, Martins, João Pedro, Celia, Christian, Palumbo, Paola, Lombardi, Francesca, Iannotta, Dalila, Di Marzio, Luisa, Santos, Hélder A. and Viitala, Tapani (2023). In vitro characterization and real-time label-free assessment of the interaction of chitosan-coated niosomes with intestinal cellular monolayers. Langmuir, 39 (23), 8255-8266. doi: 10.1021/acs.langmuir.3c00728

Busatto, Sara, Yang, Yubo, Iannotta, Dalila, Davidovich, Irina, Talmon, Yeshayahu and Wolfram, Joy (2022). Considerations for extracellular vesicle and lipoprotein interactions in cell culture assays. Journal of Extracellular Vesicles, 11 (4) e12202, e12202. doi: 10.1002/jev2.12202

Wang, Xinghua, Pham, Anthony, Kang, Lu, Walker, Sierra A., Davidovich, Irina, Iannotta, Dalila, Terkonda, Sarvam P., Shapiro, Shane, Talmon, Yeshayahu, Pham, Si and Wolfram, Joy (2022). Effects of adipose-derived biogenic nanoparticle-associated microrna-451a on toll-like receptor 4-induced cytokines. Pharmaceutics, 14 (1) 16, 16. doi: 10.3390/pharmaceutics14010016

Iannotta, Dalila, Yang, Man, Celia, Christian, Di Marzio, Luisa and Wolfram, Joy (2021). Extracellular vesicle therapeutics from plasma and adipose tissue. Nano Today, 39 101159, 101159. doi: 10.1016/j.nantod.2021.101159

Busatto, Sara, Iannotta, Dalila, Walker, Sierra A., Di Marzio, Luisa and Wolfram, Joy (2021). A simple and quick method for loading proteins in extracellular vesicles. Pharmaceuticals, 14 (4) 356, 356. doi: 10.3390/ph14040356

Vergallo, Cristian, Hafeez, Muhammad Nadeem, Iannotta, Dalila, Santos, Helder A., D'Avanzo, Nicola, Dini, Luciana, Cilurzo, Felisa, Fresta, Massimo, Di Marzio, Luisa and Christian, Celia (2021). Conventional nanosized drug delivery systems for cancer applications. Bio-Nanomedicine for Cancer Therapy, 1295, 3-27. doi: 10.1007/978-3-030-58174-9_1

Barone, Antonella, Cristiano, Maria Chiara, Cilurzo, Felisa, Locatelli, Marcello, Iannotta, Dalila, Di Marzio, Luisa, Celia, Christian and Paolino, Donatella (2020). Ammonium glycyrrhizate skin delivery from ultradeformable liposomes: A novel use as an anti-inflammatory agent in topical drug delivery. Colloids and Surfaces B: Biointerfaces, 193 111152, 111152. doi: 10.1016/j.colsurfb.2020.111152

D'Angelo, Michele, Antonosante, Andrea, Castelli, Vanessa, Catanesi, Mariano, Moorthy, NandhaKumar, Iannotta, Dalila, Cimini, Annamaria and Benedetti, Elisabetta (2018). PPARs and energy metabolism adaptation during neurogenesis and neuronal maturation. International Journal of Molecular Sciences, 19 (7) 1869, 1-16. doi: 10.3390/ijms19071869

Antonosante, Andrea, d'Angelo, Michele, Castelli, Vanessa, Catanesi, Mariano, Iannotta, Dalila, Giordano, Antonio, Ippoliti, Rodolfo, Benedetti, Elisabetta and Cimini, Annamaria (2018). The involvement of PPARs in the peculiar energetic metabolism of tumor cells. International Journal of Molecular Sciences, 19 (7) 1907, 1-30. doi: 10.3390/ijms19071907

Castelli, Vanessa, Palumbo, Paola, d'Angelo, Michele, Moorthy, Nandha Kumar, Antonosante, Andrea, Catanesi, Mariano, Lombardi, Francesca, Iannotta, Dalila, Cinque, Benedetta, Benedetti, Elisabetta, Ippoliti, Rodolfo, Cifone, Maria Grazia and Cimini, Annamaria (2018). Probiotic DSF counteracts chemotherapy induced neuropathic pain. OncoTarget, 9 (46), 27998-28008. doi: 10.18632/oncotarget.25524

Conference Papers

Iannotta, Dalila, Busatto, Sara, Yang, Yubo, Davidovich, Irina, Talmon, Yeshayahu and Wolfram, Joy (2022). Consideration for extracellular vesicle and lipoprotein interactions in cell culture assays. Australia and New Zealand Society for Extracellular Vesicles Annual Meeting, Gold Coast, QLD, Australia , 9-11 November 2022.

Iannotta, Dalila, Celia, Christian , Wolfram, Joy, Agata, P. and Di Marzio, Luisa (2020). Discoidal nanoparticles: reaction environment-dependent size response. NanoInnovation 2020, Rome, Italy , September 2020.

Iannotta, Dalila, Celia, Christian, Wolfram, Joy, Agata, P. and Di Marzio, Luisa (2020). Hybrid nanocarrier library based biomaterials for therapeutic applications. 1st International Northern Southern Europe Workshop in Nanomedicine, Chieti, Italy, January 2020.